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Assay Detail

CHEMBL3226836

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK3 (unknown origin) using biotinylated ATF2 by HTRF method
ChEMBL ↗
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 10 (CHEMBL2637) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors
Song X, He Y, Koenig M, Shin Y, Noel R, Chen W, Ling YY, Feurstein D, Lin L, Ruiz CH, Cameron MD, Duckett DR, Kamenecka TM
Medchemcomm (2012) 3 : 238 -243
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 7.24 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3220502 — — 1 9.80
CHEMBL3220499 — — 1 9.60
CHEMBL3220497 — — 1 9.55
CHEMBL3220493 — — 1 9.55
CHEMBL3220496 — — 1 9.52
CHEMBL3220498 — — 1 9.51
CHEMBL3220494 — — 1 9.38
CHEMBL3220500 — — 1 9.11
CHEMBL3220495 — — 1 9.11
CHEMBL3217784 — — 1 8.92
CHEMBL3220501 — — 1 8.60
CHEMBL458997 — — 1 7.92
CHEMBL3220469 — — 1 7.21
CHEMBL3220467 — — 1 7.17
CHEMBL3220466 — — 1 7.08
CHEMBL3220483 — — 1 6.88
CHEMBL3040440 VS-4718 1.0 1 6.80
CHEMBL3220479 — — 1 6.80
CHEMBL3220477 — — 1 6.76
CHEMBL3220492 — — 1 6.76
CHEMBL3220471 — — 1 6.66
CHEMBL3220486 — — 1 6.66
CHEMBL3220465 — — 1 6.50
CHEMBL3220489 — — 1 6.49
CHEMBL3220485 — — 1 6.49
CHEMBL3220470 — — 1 6.49
CHEMBL3220474 — — 1 6.49
CHEMBL3220484 — — 1 6.43
CHEMBL3220487 — — 1 6.43
CHEMBL3220472 — — 1 6.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3220502 — IC50 = 0.16 nM 9.80
CHEMBL3220499 — IC50 = 0.25 nM 9.60
CHEMBL3220493 — IC50 = 0.28 nM 9.55
CHEMBL3220497 — IC50 = 0.28 nM 9.55
CHEMBL3220496 — IC50 = 0.3 nM 9.52
CHEMBL3220498 — IC50 = 0.31 nM 9.51
CHEMBL3220494 — IC50 = 0.42 nM 9.38
CHEMBL3220500 — IC50 = 0.77 nM 9.11
CHEMBL3220495 — IC50 = 0.78 nM 9.11
CHEMBL3217784 — IC50 = 1.2 nM 8.92
CHEMBL3220501 — IC50 = 2.5 nM 8.60
CHEMBL458997 — IC50 = 12.0 nM 7.92
CHEMBL3220469 — IC50 = 61.0 nM 7.21
CHEMBL3220467 — IC50 = 68.0 nM 7.17
CHEMBL3220466 — IC50 = 83.0 nM 7.08
CHEMBL3220483 — IC50 = 132.0 nM 6.88
CHEMBL3040440 VS-4718 IC50 = 160.0 nM 6.80
CHEMBL3220479 — IC50 = 160.0 nM 6.80
CHEMBL3220477 — IC50 = 173.0 nM 6.76
CHEMBL3220492 — IC50 = 173.0 nM 6.76
CHEMBL3220486 — IC50 = 218.0 nM 6.66
CHEMBL3220471 — IC50 = 218.0 nM 6.66
CHEMBL3220465 — IC50 = 320.0 nM 6.50
CHEMBL3220489 — IC50 = 326.0 nM 6.49
CHEMBL3220485 — IC50 = 325.0 nM 6.49
CHEMBL3220470 — IC50 = 325.0 nM 6.49
CHEMBL3220474 — IC50 = 326.0 nM 6.49
CHEMBL3220484 — IC50 = 374.0 nM 6.43
CHEMBL3220487 — IC50 = 371.0 nM 6.43
CHEMBL3220472 — IC50 = 371.0 nM 6.43
CHEMBL3220490 — IC50 = 414.0 nM 6.38
CHEMBL3220475 — IC50 = 414.0 nM 6.38
CHEMBL3220468 — IC50 = 510.0 nM 6.29
CHEMBL3220488 — IC50 = 680.0 nM 6.17
CHEMBL3220473 — IC50 = 680.0 nM 6.17
CHEMBL3220476 — IC50 = 727.0 nM 6.14
CHEMBL3220491 — IC50 = 727.0 nM 6.14
CHEMBL3220503 — IC50 = 1000.0 nM 6.00
CHEMBL3220504 — IC50 = 1800.0 nM 5.75
CHEMBL3220478 — IC50 = 3100.0 nM 5.51
CHEMBL3220481 — IC50 = 12000.0 nM 4.92
CHEMBL3220482 — IC50 > 20000.0 nM -
CHEMBL3220480 — IC50 > 20000.0 nM -