Assay Detail
Binding
CHEMBL3226862
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38 MAP kinase-mediated MAPKAPK2 phosphorylation in human U937 cells after 4 hrs by chemiluminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Monocyte and macrophage selective anti-inflammatory kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.73 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220549 | — | — | 1 | 9.19 |
| CHEMBL3220550 | — | — | 1 | 9.00 |
| CHEMBL3220548 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220549 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3220550 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3220548 | — | IC50 | = | 10.0 | nM | 8.00 |