Assay Detail
Binding
CHEMBL3227038
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Inhibition of LIMK1 (unknown origin) using cofilin-2 as substrate after 60 mins by Kinase-Glo assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.08 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836361 | — | — | 1 | 6.58 |
| CHEMBL1836360 | — | — | 1 | 6.52 |
| CHEMBL3219028 | — | — | 1 | 6.16 |
| CHEMBL3219008 | — | — | 1 | 5.89 |
| CHEMBL3219011 | — | — | 1 | 5.80 |
| CHEMBL3219012 | — | — | 1 | 5.70 |
| CHEMBL1483395 | — | — | 1 | 5.55 |
| CHEMBL1571017 | — | — | 1 | 5.52 |
| CHEMBL3219024 | — | — | 1 | 5.40 |
| CHEMBL1836359 | — | — | 1 | 5.40 |
| CHEMBL3219025 | — | — | 1 | 5.26 |
| CHEMBL3219026 | — | — | 1 | 5.24 |
| CHEMBL3219027 | — | — | 1 | 5.21 |
| CHEMBL1836358 | — | — | 1 | 5.16 |
| CHEMBL1269082 | — | — | 1 | 5.15 |
| CHEMBL377085 | — | — | 1 | 5.05 |
| CHEMBL457313 | — | — | 1 | 5.05 |
| CHEMBL3218815 | — | — | 1 | 4.96 |
| CHEMBL3219023 | — | — | 1 | 4.82 |
| CHEMBL3219009 | — | — | 1 | 4.52 |
| CHEMBL211002 | — | — | 1 | 4.48 |
| CHEMBL3219018 | — | — | 1 | 4.47 |
| CHEMBL207012 | — | — | 1 | 4.43 |
| CHEMBL578181 | — | — | 1 | 4.43 |
| CHEMBL3219010 | — | — | 1 | 4.39 |
| CHEMBL3219029 | — | — | 1 | 4.37 |
| CHEMBL2153531 | — | — | 1 | 4.37 |
| CHEMBL3219013 | — | — | 1 | 4.36 |
| CHEMBL568904 | — | — | 1 | 4.25 |
| CHEMBL3219021 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836361 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1836360 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3219028 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3219008 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3219011 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3219012 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1483395 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1571017 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3219024 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1836359 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3219025 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3219026 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3219027 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1836358 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1269082 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL377085 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL457313 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3218815 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3219023 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3219009 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL211002 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3219018 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL207012 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL578181 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3219010 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL3219029 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2153531 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL3219013 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL568904 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL3219021 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL3219014 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3217769 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3219015 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3219016 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3219017 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3219019 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL538197 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3219020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3219022 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2153541 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3219030 | — | IC50 | > | 50000.0 | nM | - |