Assay Detail
Binding
CHEMBL3227039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-N-methyl scopolamine from human cloned muscarinic M3 receptor
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimized glucuronidation of dual pharmacology -2 agonists/M3 antagonists for the treatment of COPD
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 8.32 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3219031 | — | — | 1 | 9.41 |
| CHEMBL3219042 | — | — | 1 | 9.14 |
| CHEMBL1683934 | — | — | 1 | 9.09 |
| CHEMBL3219048 | — | — | 1 | 8.96 |
| CHEMBL3219046 | — | — | 1 | 8.96 |
| CHEMBL3219053 | — | — | 1 | 8.89 |
| CHEMBL3219049 | — | — | 1 | 8.70 |
| CHEMBL3219044 | — | — | 1 | 8.70 |
| CHEMBL3219032 | — | — | 1 | 8.66 |
| CHEMBL3219056 | — | — | 1 | 8.51 |
| CHEMBL3219033 | — | — | 1 | 8.43 |
| CHEMBL3219052 | — | — | 1 | 8.37 |
| CHEMBL3219047 | — | — | 1 | 8.36 |
| CHEMBL3219050 | — | — | 1 | 8.36 |
| CHEMBL3219043 | — | — | 1 | 8.32 |
| CHEMBL3219040 | — | — | 1 | 8.30 |
| CHEMBL3219041 | — | — | 1 | 8.08 |
| CHEMBL3219054 | — | — | 1 | 8.05 |
| CHEMBL3219051 | — | — | 1 | 8.04 |
| CHEMBL3219036 | — | — | 1 | 8.00 |
| CHEMBL3219034 | — | — | 1 | 7.75 |
| CHEMBL3219038 | — | — | 1 | 7.66 |
| CHEMBL3219035 | — | — | 1 | 7.58 |
| CHEMBL3219055 | — | — | 1 | 7.44 |
| CHEMBL3219045 | — | — | 1 | 7.42 |
| CHEMBL3219039 | — | — | 1 | 7.12 |
| CHEMBL3219037 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3219031 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL3219042 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL1683934 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL3219048 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3219046 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3219053 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL3219049 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3219044 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3219032 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL3219056 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL3219033 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL3219052 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL3219047 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL3219050 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL3219043 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL3219040 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3219041 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL3219054 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL3219051 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3219036 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3219034 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3219038 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3219035 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3219055 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL3219045 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3219039 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL3219037 | — | Ki | > | 73.0 | nM | - |