Assay Detail
Binding
CHEMBL3227239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 25-[3H]hydroxycholesterol from GST-tagged ROR alpha ligand binding domain (unknown origin) expressed in Escherichia coli BL21 gold (DE3) cells by radioligand competition assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic modulators of the retinoic acid receptor-related orphan receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.34 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497207 | — | — | 1 | 7.92 |
| CHEMBL497834 | — | — | 1 | 7.92 |
| CHEMBL1278177 | 7-OXOCHOLESTEROL | — | 1 | 7.92 |
| CHEMBL62136 | T091317 | — | 1 | 6.88 |
| CHEMBL3094388 | — | — | 1 | 6.76 |
| CHEMBL3218916 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497207 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL497834 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1278177 | 7-OXOCHOLESTEROL | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL62136 | T091317 | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL3094388 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL3218916 | — | Ki | = | 220.0 | nM | 6.66 |