Assay Detail
Binding
CHEMBL3227489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-MIP-1alpha from CCR5 in rhesus monkey Chem-1 cell membranes after 120 mins by liquid scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca mulatta |
| Cell Type | Chem-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.72 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256907 | MARAVIROC | 4.0 | 1 | 9.62 |
| CHEMBL3219780 | — | — | 1 | 7.82 |
| CHEMBL3219779 | — | — | 1 | 6.82 |
| CHEMBL3219777 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256907 | MARAVIROC | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL3219780 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL3219779 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL3219777 | — | Ki | = | 239.0 | nM | 6.62 |