Assay Detail
Binding
CHEMBL3227740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat FAAH expressed in HEK293 cells using arachadonyl 7-amino 4-methyl coumarin amide as substrate by fluorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Amino-5-arylbenzoxazole derivatives as potent inhibitors of fatty acid amide hydrolase (FAAH)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.38 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184238 | URB-597 | 1.0 | 1 | 9.15 |
| CHEMBL560590 | — | — | 1 | 7.77 |
| CHEMBL3222191 | — | — | 1 | 6.38 |
| CHEMBL3217947 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184238 | URB-597 | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL560590 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3222191 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL3217947 | — | IC50 | = | 586.0 | nM | 6.23 |