Assay Detail
Binding
CHEMBL3227741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversible inhibition of full length human FAAH assessed as inhibition of 3[H]-anandamide hydrolysis preincubated for 3 hrs measured after 15 mins post substrate addition by cell-based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Amino-5-arylbenzoxazole derivatives as potent inhibitors of fatty acid amide hydrolase (FAAH)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.93 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217947 | — | — | 1 | 7.04 |
| CHEMBL3222191 | — | — | 1 | 7.02 |
| CHEMBL422064 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217947 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3222191 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL422064 | — | IC50 | = | 187.0 | nM | 6.73 |