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Assay Detail

CHEMBL3227814

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli DHPS
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Dihydropteroate synthase (CHEMBL2364668)
Type SINGLE PROTEIN
Organism Bacteria

Publication

Antifolates as effective antimicrobial agents: new generations of trimethoprim analogs
Zhou W, Scocchera EW, Wright DL, Anderson AC
Medchemcomm (2013) 4 : 908 -915
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.16 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL159139 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL159139 IC50 = 700.0 nM 6.16