Assay Detail
Binding
CHEMBL3227826
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Inhibition of methicillin-resistant Staphylococcus aureus DHFR F98Y mutant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antifolates as effective antimicrobial agents: new generations of trimethoprim analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.36 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2335419 | — | — | 1 | 6.77 |
| CHEMBL520358 | — | — | 1 | 6.72 |
| CHEMBL485961 | — | — | 1 | 6.17 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2335419 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL520358 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL485961 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 1700.0 | nM | 5.77 |