Assay Detail
Functional
CHEMBL3232126
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Antagonism of slow reacting substance of anaphylaxis-induced effect in guinea pig ileum
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aryloxyalkyloxy- and aralkyloxy-4-hydroxy-3-nitrocoumarins which inhibit histamine release in the rat and also antagonize the effects of a slow reacting substance of anaphylaxis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 5.84 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3230381 | — | — | 1 | 7.60 |
| CHEMBL3230383 | — | — | 1 | 7.30 |
| CHEMBL3230378 | — | — | 1 | 7.10 |
| CHEMBL3230262 | — | — | 1 | 7.00 |
| CHEMBL3230266 | — | — | 1 | 6.96 |
| CHEMBL3230267 | — | — | 1 | 6.85 |
| CHEMBL3230379 | — | — | 1 | 6.82 |
| CHEMBL3230268 | — | — | 1 | 6.80 |
| CHEMBL267475 | FPL-55712 | — | 1 | 6.77 |
| CHEMBL3230384 | — | — | 1 | 6.70 |
| CHEMBL3230271 | — | — | 1 | 6.30 |
| CHEMBL3230248 | — | — | 1 | 6.27 |
| CHEMBL3230258 | — | — | 1 | 6.23 |
| CHEMBL3230269 | — | — | 1 | 6.16 |
| CHEMBL3230229 | — | — | 1 | 6.11 |
| CHEMBL3230249 | — | — | 1 | 6.00 |
| CHEMBL3230240 | — | — | 1 | 5.82 |
| CHEMBL3230231 | — | — | 1 | 5.80 |
| CHEMBL3230382 | — | — | 1 | 5.80 |
| CHEMBL3230228 | — | — | 1 | 5.70 |
| CHEMBL3230227 | — | — | 1 | 5.64 |
| CHEMBL3230245 | — | — | 1 | 5.60 |
| CHEMBL3230265 | — | — | 1 | 5.57 |
| CHEMBL3230260 | — | — | 1 | 5.55 |
| CHEMBL3230380 | — | — | 1 | 5.46 |
| CHEMBL3230232 | — | — | 1 | 5.44 |
| CHEMBL3230244 | — | — | 1 | 5.42 |
| CHEMBL3230250 | — | — | 1 | 5.40 |
| CHEMBL3230257 | — | — | 1 | 5.36 |
| CHEMBL3230241 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3230381 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3230383 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3230378 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3230262 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3230266 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3230267 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3230379 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3230268 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL267475 | FPL-55712 | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3230384 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3230271 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3230248 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3230258 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3230269 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3230229 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3230249 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3230240 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3230231 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3230382 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3230228 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3230227 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3230245 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3230265 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3230260 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3230380 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3230232 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3230244 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3230250 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3230257 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3230241 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3230256 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3230243 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3230246 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3230239 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3230252 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3230242 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3230233 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3230263 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3230226 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3230224 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3230238 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3230237 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3230264 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3230261 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3230254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3230253 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3230255 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3228069 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3230270 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3230225 | — | IC50 | > | 10000.0 | nM | - |