Assay Detail
Functional
CHEMBL3238601
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Antiproliferative activity against human H460 cells assessed as growth inhibition after 72 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.66 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3235463 | — | — | 1 | 6.08 |
| CHEMBL3235788 | — | — | 1 | 6.00 |
| CHEMBL3235791 | — | — | 1 | 6.00 |
| CHEMBL3235792 | — | — | 1 | 5.89 |
| CHEMBL3235787 | — | — | 1 | 5.85 |
| CHEMBL3235464 | — | — | 1 | 5.85 |
| CHEMBL3235789 | — | — | 1 | 5.62 |
| CHEMBL3235790 | — | — | 1 | 5.57 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.47 |
| CHEMBL561209 | — | — | 1 | 5.43 |
| CHEMBL556532 | — | — | 1 | 5.27 |
| CHEMBL375062 | — | — | 1 | 5.27 |
| CHEMBL556332 | — | — | 1 | 5.22 |
| CHEMBL3235462 | — | — | 1 | - |
| CHEMBL538364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3235463 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3235788 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3235791 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3235792 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3235787 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3235464 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL3235789 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3235790 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL561209 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL556532 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL375062 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL556332 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3235462 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL538364 | — | IC50 | > | 20000.0 | nM | - |