Assay Detail
Functional
CHEMBL3238604
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Antiproliferative activity against p53 defective cis-platinum-resistant human IGROV1/Pt1 cells assessed as growth inhibition after 72 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.67 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3235788 | — | — | 1 | 6.10 |
| CHEMBL3235791 | — | — | 1 | 5.96 |
| CHEMBL3235463 | — | — | 1 | 5.89 |
| CHEMBL3235789 | — | — | 1 | 5.87 |
| CHEMBL375062 | — | — | 1 | 5.80 |
| CHEMBL3235790 | — | — | 1 | 5.80 |
| CHEMBL3235464 | — | — | 1 | 5.75 |
| CHEMBL538364 | — | — | 1 | 5.70 |
| CHEMBL3235787 | — | — | 1 | 5.69 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.66 |
| CHEMBL561209 | — | — | 1 | 5.64 |
| CHEMBL3235792 | — | — | 1 | 5.38 |
| CHEMBL556532 | — | — | 1 | 5.37 |
| CHEMBL3235462 | — | — | 1 | 5.24 |
| CHEMBL556332 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3235788 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3235791 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3235463 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3235789 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL375062 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3235790 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3235464 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL538364 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL3235787 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL561209 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3235792 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL556532 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3235462 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL556332 | — | IC50 | = | 6500.0 | nM | 5.19 |