Assay Detail
Binding
CHEMBL3238627
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Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.20 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011499 | — | — | 1 | 6.77 |
| CHEMBL536047 | — | — | 1 | 6.74 |
| CHEMBL2007996 | — | — | 1 | 6.65 |
| CHEMBL3233831 | — | — | 1 | 6.58 |
| CHEMBL3233829 | — | — | 1 | 6.46 |
| CHEMBL3233832 | — | — | 1 | 6.29 |
| CHEMBL3234040 | — | — | 1 | 6.29 |
| CHEMBL3233830 | — | — | 1 | 6.21 |
| CHEMBL3234039 | — | — | 1 | 6.19 |
| CHEMBL3233826 | — | — | 1 | 6.02 |
| CHEMBL3233827 | — | — | 1 | 5.97 |
| CHEMBL3234038 | — | — | 1 | 5.96 |
| CHEMBL3233828 | — | — | 1 | 5.84 |
| CHEMBL418068 | RHEIN | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011499 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL536047 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL2007996 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL3233831 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL3233829 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3233832 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL3234040 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3233830 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3234039 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL3233826 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3233827 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL3234038 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3233828 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL418068 | RHEIN | IC50 | = | 17000.0 | nM | 4.77 |