Assay Detail
Binding
CHEMBL3239059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PTP1B (unknown origin) using nitrophenyl phosphate as substrate after 30 mins by spectrophotometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly conjugated norditerpenoid and pyrroloquinoline alkaloids with potent PTP1B inhibitory activity from Nigella glandulifera.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.03 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3235604 | — | — | 1 | 5.19 |
| CHEMBL1232829 | — | — | 1 | 5.17 |
| CHEMBL3235602 | — | — | 1 | 5.01 |
| CHEMBL3235601 | — | — | 1 | 5.00 |
| CHEMBL3235603 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3235604 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL1232829 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL3235602 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL3235601 | — | IC50 | = | 9970.0 | nM | 5.00 |
| CHEMBL3235603 | — | IC50 | = | 16850.0 | nM | 4.77 |