Assay Detail
Binding
CHEMBL3239251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His6x-tagged recombinant PRMT1 (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]SAM and histone H4 (1 to 20) as substrate after 8 mins by P81 filter binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 1 (CHEMBL5524) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.00 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424121 | — | — | 1 | 5.14 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 5.03 |
| CHEMBL142304 | STILBAMIDINE | 2.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424121 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL142304 | STILBAMIDINE | IC50 | = | 15200.0 | nM | 4.82 |