Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3239394

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Tissue Vas deferens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Delta-type opioid receptor (CHEMBL3222)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity.
Cai J, Song B, Cai Y, Ma Y, Lam AL, Magiera J, Sekar S, Wyse BD, Ambo A, Sasaki Y, Lazarus LH, Smith MT, Li T.
Bioorg Med Chem (2014) 22 : 2208 -2219
PubMed 24613457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.72 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL340032 DADLE 1 8.80
CHEMBL120758 1 6.95
CHEMBL3233200 1 6.13
CHEMBL3233198 1 5.00
CHEMBL365983 1 -
CHEMBL3233191 1 -
CHEMBL3233192 1 -
CHEMBL3233193 1 -
CHEMBL3233194 1 -
CHEMBL3233195 1 -
CHEMBL3233196 1 -
CHEMBL3233197 1 -
CHEMBL3233199 1 -
CHEMBL3233014 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL340032 DADLE IC50 = 1.6 nM 8.80
CHEMBL120758 IC50 = 113.0 nM 6.95
CHEMBL3233200 IC50 = 745.0 nM 6.13
CHEMBL3233198 IC50 = 10000.0 nM 5.00
CHEMBL365983 IC50 > 10000.0 nM -
CHEMBL3233191 IC50 > 10000.0 nM -
CHEMBL3233192 IC50 > 10000.0 nM -
CHEMBL3233193 IC50 > 10000.0 nM -
CHEMBL3233194 IC50 > 10000.0 nM -
CHEMBL3233195 IC50 > 10000.0 nM -
CHEMBL3233196 IC50 > 10000.0 nM -
CHEMBL3233197 IC50 > 10000.0 nM -
CHEMBL3233199 IC50 > 10000.0 nM -
CHEMBL3233014 IC50 > 10000.0 nM -