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Assay Detail

CHEMBL3239529

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse J774A1 cells after 24 hrs by neutral red dye uptake assay
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type J774.A1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Anti-mycobacterial activity of 1,3-diaryltriazenes.
Cappoen D, Vajs J, Uythethofken C, Virag A, Mathys V, Kočevar M, Verschaeve L, Gazvoda M, Polanc S, Huygen K, Košmrlj J.
Eur J Med Chem (2014) 77 : 193 -203
PubMed 24631899 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.03 6.21
I50 12 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1807121 1 6.21
CHEMBL1806504 1 5.97
CHEMBL3237104 1 5.68
CHEMBL3237095 1 5.41
CHEMBL3237094 1 5.29
CHEMBL3237105 1 5.16
CHEMBL353640 1 5.01
CHEMBL1807122 1 4.93
CHEMBL1807123 1 4.89
CHEMBL3237103 1 4.68
CHEMBL1807075 1 4.62
CHEMBL3237102 1 4.58
CHEMBL3237100 1 4.55
CHEMBL3237096 1 4.28
CHEMBL1807078 1 4.26
CHEMBL1807074 1 -
CHEMBL3237101 1 -
CHEMBL170666 1 -
CHEMBL3237106 1 -
CHEMBL3237099 1 -
CHEMBL3237107 1 -
CHEMBL3237092 1 -
CHEMBL3237093 1 -
CHEMBL1807085 1 -
CHEMBL3237098 1 -
CHEMBL3237097 1 -
CHEMBL64 ISONIAZID 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1807121 IC50 = 610.0 nM 6.21
CHEMBL1806504 IC50 = 1070.0 nM 5.97
CHEMBL3237104 IC50 = 2090.0 nM 5.68
CHEMBL3237095 IC50 = 3940.0 nM 5.41
CHEMBL3237094 IC50 = 5120.0 nM 5.29
CHEMBL3237105 IC50 = 6870.0 nM 5.16
CHEMBL353640 IC50 = 9690.0 nM 5.01
CHEMBL1807122 IC50 = 11630.0 nM 4.93
CHEMBL1807123 IC50 = 12900.0 nM 4.89
CHEMBL3237103 IC50 = 21100.0 nM 4.68
CHEMBL1807075 IC50 = 24220.0 nM 4.62
CHEMBL3237102 IC50 = 26030.0 nM 4.58
CHEMBL3237100 IC50 = 28180.0 nM 4.55
CHEMBL3237096 IC50 = 52680.0 nM 4.28
CHEMBL1807078 IC50 = 55220.0 nM 4.26
CHEMBL1807074 I50 - -
CHEMBL3237101 I50 - -
CHEMBL170666 I50 - -
CHEMBL3237106 I50 - -
CHEMBL3237099 I50 - -
CHEMBL3237107 I50 - -
CHEMBL3237092 I50 - -
CHEMBL3237093 I50 - -
CHEMBL1807085 I50 - -
CHEMBL3237098 I50 - -
CHEMBL3237097 I50 - -
CHEMBL64 ISONIAZID I50 - -