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Assay Detail

CHEMBL3239619

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of DPP4 in mouse plasma
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Tissue Plasma
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dipeptidyl peptidase 4 (CHEMBL3883)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.
Biftu T, Sinha-Roy R, Chen P, Qian X, Feng D, Kuethe JT, Scapin G, Gao YD, Yan Y, Krueger D, Bak A, Eiermann G, He J, Cox J, Hicks J, Lyons K, He H, Salituro G, Tong S, Patel S, Doss G, Petrov A, Wu J, Xu SS, Sewall C, Zhang X, Zhang B, Thornberry NA, Weber AE.
J Med Chem (2014) 57 : 3205 -3212
PubMed 24660890 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.36 7.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2105762 OMARIGLIPTIN 4.0 1 7.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2105762 OMARIGLIPTIN IC50 = 43.9 nM 7.36