Assay Detail
Functional
CHEMBL3240086
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Inhibition of human HCT116 cell growth
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.01 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.30 |
| CHEMBL3237863 | — | — | 1 | 7.50 |
| CHEMBL3237864 | — | — | 1 | 7.37 |
| CHEMBL3237870 | — | — | 1 | 7.35 |
| CHEMBL3237862 | — | — | 1 | 7.34 |
| CHEMBL3237869 | — | — | 1 | 7.22 |
| CHEMBL3237865 | — | — | 1 | 7.20 |
| CHEMBL3237867 | — | — | 1 | 7.17 |
| CHEMBL3237874 | — | — | 1 | 7.10 |
| CHEMBL3237866 | — | — | 1 | 6.96 |
| CHEMBL3237873 | — | — | 1 | 6.89 |
| CHEMBL3237868 | — | — | 1 | 6.85 |
| CHEMBL3237871 | — | — | 1 | 6.58 |
| CHEMBL3237860 | — | — | 1 | 5.74 |
| CHEMBL3237872 | — | — | 1 | 5.60 |
| CHEMBL3237861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237863 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL3237864 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3237870 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3237862 | — | IC50 | = | 45.4 | nM | 7.34 |
| CHEMBL3237869 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3237865 | — | IC50 | = | 63.6 | nM | 7.20 |
| CHEMBL3237867 | — | IC50 | = | 67.2 | nM | 7.17 |
| CHEMBL3237874 | — | IC50 | = | 79.6 | nM | 7.10 |
| CHEMBL3237866 | — | IC50 | = | 110.3 | nM | 6.96 |
| CHEMBL3237873 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3237868 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3237871 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3237860 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL3237872 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3237861 | — | IC50 | > | 10000.0 | nM | - |