Assay Detail
Binding
CHEMBL3240089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta5i subunit of immunoproteasome (unknown origin) by active-site ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.05 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237863 | — | — | 1 | 7.51 |
| CHEMBL3237873 | — | — | 1 | 7.23 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.11 |
| CHEMBL3237875 | — | — | 1 | 6.35 |
| CHEMBL374308 | LACTACYSTIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237863 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3237873 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3237875 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL374308 | LACTACYSTIN | IC50 | > | 3000.0 | nM | - |