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Assay Detail

CHEMBL3240191

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of SIRT-2 (unknown origin) by fluorescence assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Khanfar MA, Quinti L, Wang H, Choi SH, Kazantsev AG, Silverman RB.
Eur J Med Chem (2014) 76 : 414 -426
PubMed 24602787 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.03 5.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3237064 1 5.42
CHEMBL3237040 1 5.31
CHEMBL3236972 1 5.21
CHEMBL3237032 1 5.21
CHEMBL3237063 1 5.20
CHEMBL3237039 1 5.18
CHEMBL3237010 1 5.17
CHEMBL3237038 1 5.16
CHEMBL3237014 1 5.14
CHEMBL3237037 1 5.12
CHEMBL3236962 1 5.04
CHEMBL3236703 1 5.03
CHEMBL3237023 1 5.02
CHEMBL3236967 1 5.02
CHEMBL3236998 1 5.02
CHEMBL3236969 1 5.01
CHEMBL3237041 1 4.99
CHEMBL1797749 1 4.97
CHEMBL3237034 1 4.94
CHEMBL3237011 1 4.88
CHEMBL3236707 1 4.81
CHEMBL3237025 1 4.80
CHEMBL3236708 1 4.79
CHEMBL3237017 1 4.72
CHEMBL3236980 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3237064 IC50 = 3800.0 nM 5.42
CHEMBL3237040 IC50 = 4900.0 nM 5.31
CHEMBL3236972 IC50 = 6100.0 nM 5.21
CHEMBL3237032 IC50 = 6100.0 nM 5.21
CHEMBL3237063 IC50 = 6300.0 nM 5.20
CHEMBL3237039 IC50 = 6600.0 nM 5.18
CHEMBL3237010 IC50 = 6800.0 nM 5.17
CHEMBL3237038 IC50 = 6900.0 nM 5.16
CHEMBL3237014 IC50 = 7300.0 nM 5.14
CHEMBL3237037 IC50 = 7500.0 nM 5.12
CHEMBL3236962 IC50 = 9100.0 nM 5.04
CHEMBL3236703 IC50 = 9400.0 nM 5.03
CHEMBL3237023 IC50 = 9500.0 nM 5.02
CHEMBL3236967 IC50 = 9500.0 nM 5.02
CHEMBL3236998 IC50 = 9600.0 nM 5.02
CHEMBL3236969 IC50 = 9800.0 nM 5.01
CHEMBL3237041 IC50 = 10200.0 nM 4.99
CHEMBL1797749 IC50 = 10800.0 nM 4.97
CHEMBL3237034 IC50 = 11500.0 nM 4.94
CHEMBL3237011 IC50 = 13200.0 nM 4.88
CHEMBL3236707 IC50 = 15600.0 nM 4.81
CHEMBL3237025 IC50 = 15900.0 nM 4.80
CHEMBL3236708 IC50 = 16100.0 nM 4.79
CHEMBL3237017 IC50 = 18900.0 nM 4.72
CHEMBL3236980 IC50 = 19900.0 nM 4.70