Assay Detail
Binding
CHEMBL3240324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATP
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.39 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237702 | — | — | 1 | 9.00 |
| CHEMBL3237704 | — | — | 1 | 9.00 |
| CHEMBL3237711 | — | — | 1 | 9.00 |
| CHEMBL3237442 | — | — | 1 | 8.70 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 8.70 |
| CHEMBL3237710 | — | — | 1 | 8.70 |
| CHEMBL3237709 | — | — | 1 | 8.70 |
| CHEMBL3237708 | — | — | 1 | 8.70 |
| CHEMBL3237707 | — | — | 1 | 8.70 |
| CHEMBL3237706 | — | — | 1 | 8.52 |
| CHEMBL3237450 | — | — | 1 | 8.52 |
| CHEMBL3237705 | — | — | 1 | 8.52 |
| CHEMBL3237712 | — | — | 1 | 8.52 |
| CHEMBL3237714 | — | — | 1 | 8.52 |
| CHEMBL3237717 | — | — | 1 | 8.52 |
| CHEMBL3237719 | — | — | 1 | 8.52 |
| CHEMBL3237443 | — | — | 1 | 8.52 |
| CHEMBL3237713 | — | — | 1 | 8.52 |
| CHEMBL3237716 | — | — | 1 | 8.40 |
| CHEMBL3237444 | — | — | 1 | 8.40 |
| CHEMBL3237446 | — | — | 1 | 8.30 |
| CHEMBL3237451 | — | — | 1 | 8.30 |
| CHEMBL3237703 | — | — | 1 | 8.15 |
| CHEMBL3237715 | — | — | 1 | 8.05 |
| CHEMBL3237718 | — | — | 1 | 7.89 |
| CHEMBL3237445 | — | — | 1 | 7.70 |
| CHEMBL3237447 | — | — | 1 | 7.57 |
| CHEMBL3237449 | — | — | 1 | 7.40 |
| CHEMBL3237448 | — | — | 1 | 7.29 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237702 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3237704 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3237711 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3237442 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3237710 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3237709 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3237708 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3237707 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3237706 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237450 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237705 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237712 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237714 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237717 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237719 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237443 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237713 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3237716 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3237444 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3237446 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237451 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237703 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3237715 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3237718 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3237445 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3237447 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3237449 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3237448 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1336 | SORAFENIB | IC50 | > | 3000.0 | nM | - |