Compound Detail

CHEMBL3237445

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

Cc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL3237445
Phase	Preclinical
Structure Type	MOL
InChI Key	FLNHSHVOGZEONH-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

428.5

MW (Da)

3.95

ALogP

HBA

HBD

83.8

PSA (Å²)

0.51

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 8 meas. best 8.3

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
MOLM-13 CHEMBL3706572	IC50	8.3	8.3	5.0	1
Cyclin-dependent kinase 4/cyclin D1 CHEMBL1907601	IC50	7.7	7.7	20.0	1
Cyclin-dependent kinase 4 CHEMBL331	IC50	7.7	7.7	20.0	1
Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974	IC50	7.66	7.66	22.0	1
Cyclin-dependent kinase 6 CHEMBL2508	IC50	7.33	7.33	47.0	1
COLO 205 CHEMBL614561	IC50	6.55	6.55	280.0	1
Cyclin-dependent kinase 1/cyclin B1 CHEMBL1907602	IC50	5.65	5.65	2260.0	1
NON-PROTEIN TARGET CHEMBL3879801	IC50	5.47	5.47	3420.0	1

Parameter	Value	Units	Species
CL	-	-	Rattus norvegicus

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
MOLM-13	IC50	=	5.0	nM	8.3	Antiproliferative activity against human MOLM13 cells harboring FLT3 ITD mutant ...	24641103
Cyclin-dependent kinase 4/cyclin D1	IC50	=	20.0	nM	7.7	Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 min...	24641103
Cyclin-dependent kinase 4	IC50	=	20.0	nM	7.7	In Vitro Assay: The Cdk4 and Cdk6 inhibitory activity of the compounds is measur...	-
Receptor-type tyrosine-protein kinase FLT3	IC50	=	22.0	nM	7.66	Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) u...	24641103
Cyclin-dependent kinase 6	IC50	=	47.0	nM	7.33	In Vitro Assay: The Cdk4 and Cdk6 inhibitory activity of the compounds is measur...	-
COLO 205	IC50	=	280.0	nM	6.55	Antiproliferative activity against Rb-positive human COLO205 cells assessed as i...	24641103
Cyclin-dependent kinase 1/cyclin B1	IC50	=	2260.0	nM	5.65	Inhibition of CDK1/cyclin B (unknown origin) using histone H1 as substrate after...	24641103
NON-PROTEIN TARGET	IC50	=	3420.0	nM	5.47	Antiproliferative activity against Rb-negative human MDA-MB-436 cells assessed a...	24641103

PubMed	DOI	Target Context	# Activities
24641103	10.1021/jm500118j	Cytochrome P450 3A4	2
24641103	10.1021/jm500118j	Cyclin-dependent kinase 4/cyclin D1	1
24641103	10.1021/jm500118j	Cyclin-dependent kinase 1/cyclin B1	1
24641103	10.1021/jm500118j	Receptor-type tyrosine-protein kinase FLT3	1
24641103	10.1021/jm500118j	COLO 205	1
24641103	10.1021/jm500118j	MOLM-13	1
24641103	10.1021/jm500118j	Rattus norvegicus	1
24641103	10.1021/jm500118j	NON-PROTEIN TARGET	1

Data from ChEMBL 36 via Core Engine