Assay Detail
Functional
CHEMBL3240530
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Antiproliferative activity against Rb-negative human MDA-MB-436 cells assessed as incorporation of [3H]thymidine into DNA after 72 hrs by beta-plate counting analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-436 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.69 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237706 | — | — | 1 | 7.42 |
| CHEMBL3237451 | — | — | 1 | 6.27 |
| CHEMBL3237713 | — | — | 1 | 6.04 |
| CHEMBL3237707 | — | — | 1 | 6.00 |
| CHEMBL3237702 | — | — | 1 | 5.99 |
| CHEMBL3237712 | — | — | 1 | 5.95 |
| CHEMBL3237714 | — | — | 1 | 5.92 |
| CHEMBL3237708 | — | — | 1 | 5.92 |
| CHEMBL3237703 | — | — | 1 | 5.92 |
| CHEMBL3237709 | — | — | 1 | 5.90 |
| CHEMBL3237447 | — | — | 1 | 5.86 |
| CHEMBL3237711 | — | — | 1 | 5.83 |
| CHEMBL3237705 | — | — | 1 | 5.79 |
| CHEMBL3237442 | — | — | 1 | 5.75 |
| CHEMBL3237704 | — | — | 1 | 5.70 |
| CHEMBL3237446 | — | — | 1 | 5.68 |
| CHEMBL3237444 | — | — | 1 | 5.68 |
| CHEMBL3237710 | — | — | 1 | 5.67 |
| CHEMBL3237443 | — | — | 1 | 5.58 |
| CHEMBL3237450 | — | — | 1 | 5.58 |
| CHEMBL3237445 | — | — | 1 | 5.47 |
| CHEMBL3237719 | — | — | 1 | 5.42 |
| CHEMBL3237448 | — | — | 1 | 5.15 |
| CHEMBL3237717 | — | — | 1 | 5.14 |
| CHEMBL3237718 | — | — | 1 | 5.12 |
| CHEMBL3237715 | — | — | 1 | 5.00 |
| CHEMBL3237716 | — | — | 1 | 5.00 |
| CHEMBL3237449 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237706 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3237451 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3237713 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3237707 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3237702 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3237712 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3237714 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3237708 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3237703 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3237709 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL3237447 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL3237711 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3237705 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL3237442 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3237704 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL3237446 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3237444 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3237710 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL3237443 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL3237450 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL3237445 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL3237719 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL3237448 | — | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL3237717 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL3237718 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3237715 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3237716 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3237449 | — | IC50 | = | 30000.0 | nM | 4.52 |