Assay Detail
Binding
CHEMBL3240325
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Inhibition of CDK1/cyclin B (unknown origin) using histone H1 as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATP
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.61 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237706 | — | — | 1 | 7.62 |
| CHEMBL3237708 | — | — | 1 | 6.39 |
| CHEMBL3237712 | — | — | 1 | 6.10 |
| CHEMBL3237714 | — | — | 1 | 5.98 |
| CHEMBL3237718 | — | — | 1 | 5.97 |
| CHEMBL3237707 | — | — | 1 | 5.82 |
| CHEMBL3237713 | — | — | 1 | 5.81 |
| CHEMBL3237716 | — | — | 1 | 5.79 |
| CHEMBL3237717 | — | — | 1 | 5.75 |
| CHEMBL3237710 | — | — | 1 | 5.66 |
| CHEMBL3237719 | — | — | 1 | 5.65 |
| CHEMBL3237445 | — | — | 1 | 5.65 |
| CHEMBL3237703 | — | — | 1 | 5.58 |
| CHEMBL3237711 | — | — | 1 | 5.57 |
| CHEMBL3237704 | — | — | 1 | 5.54 |
| CHEMBL3237705 | — | — | 1 | 5.53 |
| CHEMBL3237442 | — | — | 1 | 5.52 |
| CHEMBL3237709 | — | — | 1 | 5.48 |
| CHEMBL3237444 | — | — | 1 | 5.48 |
| CHEMBL3237450 | — | — | 1 | 5.47 |
| CHEMBL3237715 | — | — | 1 | 5.40 |
| CHEMBL3237448 | — | — | 1 | 5.32 |
| CHEMBL3237702 | — | — | 1 | 5.28 |
| CHEMBL3237451 | — | — | 1 | 5.18 |
| CHEMBL3237443 | — | — | 1 | 5.12 |
| CHEMBL3237446 | — | — | 1 | 5.00 |
| CHEMBL3237449 | — | — | 1 | 4.89 |
| CHEMBL3237447 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237706 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3237708 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3237712 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3237714 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3237718 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3237707 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL3237713 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3237716 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL3237717 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL3237710 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3237719 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL3237445 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL3237703 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL3237711 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL3237704 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL3237705 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL3237442 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3237709 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL3237444 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3237450 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL3237715 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL3237448 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL3237702 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3237451 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL3237443 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL3237446 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3237449 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL3237447 | — | IC50 | = | 30000.0 | nM | 4.52 |