Assay Detail
Functional
CHEMBL3240528
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Antiproliferative activity against Rb-positive human COLO205 cells assessed as incorporation of [3H]thymidine into DNA after 72 hrs by beta-plate counting analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.42 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237708 | — | — | 1 | 8.30 |
| CHEMBL3237706 | — | — | 1 | 8.15 |
| CHEMBL3237713 | — | — | 1 | 8.05 |
| CHEMBL3237709 | — | — | 1 | 8.00 |
| CHEMBL3237710 | — | — | 1 | 7.96 |
| CHEMBL3237711 | — | — | 1 | 7.80 |
| CHEMBL3237715 | — | — | 1 | 7.72 |
| CHEMBL3237703 | — | — | 1 | 7.70 |
| CHEMBL3237707 | — | — | 1 | 7.66 |
| CHEMBL3237442 | — | — | 1 | 7.60 |
| CHEMBL3237704 | — | — | 1 | 7.55 |
| CHEMBL3237714 | — | — | 1 | 7.51 |
| CHEMBL3237717 | — | — | 1 | 7.51 |
| CHEMBL3237451 | — | — | 1 | 7.50 |
| CHEMBL3237705 | — | — | 1 | 7.48 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 7.44 |
| CHEMBL3237716 | — | — | 1 | 7.42 |
| CHEMBL3237718 | — | — | 1 | 7.36 |
| CHEMBL3237448 | — | — | 1 | 7.29 |
| CHEMBL3237443 | — | — | 1 | 7.28 |
| CHEMBL3237712 | — | — | 1 | 7.27 |
| CHEMBL3237702 | — | — | 1 | 7.26 |
| CHEMBL3237719 | — | — | 1 | 7.26 |
| CHEMBL3237444 | — | — | 1 | 7.20 |
| CHEMBL3237450 | — | — | 1 | 7.18 |
| CHEMBL3237446 | — | — | 1 | 6.92 |
| CHEMBL3237445 | — | — | 1 | 6.55 |
| CHEMBL3237447 | — | — | 1 | 6.46 |
| CHEMBL3237449 | — | — | 1 | 5.91 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237708 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237706 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3237713 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3237709 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3237710 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3237711 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3237715 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3237703 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3237707 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3237442 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3237704 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3237714 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3237717 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3237451 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3237705 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3237716 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3237718 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3237448 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3237443 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3237712 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3237702 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3237719 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3237444 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3237450 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3237446 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3237445 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3237447 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3237449 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1336 | SORAFENIB | IC50 | > | 3000.0 | nM | - |