Assay Detail
Functional
CHEMBL3240529
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Antiproliferative activity against human MOLM13 cells harboring FLT3 ITD mutant assessed as incorporation of [3H]thymidine into DNA after 72 hrs by beta-plate counting analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237712 | — | — | 1 | 8.70 |
| CHEMBL3237718 | — | — | 1 | 8.40 |
| CHEMBL3237713 | — | — | 1 | 8.40 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 8.30 |
| CHEMBL3237445 | — | — | 1 | 8.30 |
| CHEMBL3237446 | — | — | 1 | 8.30 |
| CHEMBL3237442 | — | — | 1 | 8.30 |
| CHEMBL3237706 | — | — | 1 | 8.30 |
| CHEMBL3237708 | — | — | 1 | 8.10 |
| CHEMBL3237444 | — | — | 1 | 8.05 |
| CHEMBL3237710 | — | — | 1 | 8.05 |
| CHEMBL3237709 | — | — | 1 | 8.00 |
| CHEMBL3237705 | — | — | 1 | 8.00 |
| CHEMBL3237703 | — | — | 1 | 7.89 |
| CHEMBL3237711 | — | — | 1 | 7.89 |
| CHEMBL3237707 | — | — | 1 | 7.89 |
| CHEMBL3237719 | — | — | 1 | 7.72 |
| CHEMBL3237717 | — | — | 1 | 7.68 |
| CHEMBL3237443 | — | — | 1 | 7.68 |
| CHEMBL3237450 | — | — | 1 | 7.60 |
| CHEMBL3237715 | — | — | 1 | 7.52 |
| CHEMBL3237716 | — | — | 1 | 7.50 |
| CHEMBL3237704 | — | — | 1 | 7.46 |
| CHEMBL3237714 | — | — | 1 | 7.43 |
| CHEMBL3237447 | — | — | 1 | 7.21 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 7.02 |
| CHEMBL3237702 | — | — | 1 | - |
| CHEMBL3237451 | — | — | 1 | - |
| CHEMBL3237449 | — | — | 1 | - |
| CHEMBL3237448 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237712 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3237718 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3237713 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237445 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237446 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237442 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237706 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237708 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3237444 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3237710 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3237709 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3237705 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3237703 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3237711 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3237707 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3237719 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3237717 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3237443 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3237450 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3237715 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3237716 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3237704 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3237714 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3237447 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3237702 | — | IC50 | - | — | - | |
| CHEMBL3237451 | — | IC50 | - | — | - | |
| CHEMBL3237449 | — | IC50 | - | — | - | |
| CHEMBL3237448 | — | IC50 | - | — | - |