Assay Detail
Binding
CHEMBL3240510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.17 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233601 | — | — | 1 | 8.51 |
| CHEMBL7162 | NS-398 | — | 1 | 8.15 |
| CHEMBL3233600 | — | — | 1 | 8.11 |
| CHEMBL3233602 | — | — | 1 | 8.06 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.06 |
| CHEMBL3233599 | — | — | 1 | 7.96 |
| CHEMBL3233597 | — | — | 1 | 6.35 |
| CHEMBL595838 | — | — | 1 | 6.21 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 6.07 |
| CHEMBL3233596 | — | — | 1 | 6.06 |
| CHEMBL3233598 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233601 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL7162 | NS-398 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3233600 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3233602 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL118 | CELECOXIB | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3233599 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3233597 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL595838 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3233596 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3233598 | — | IC50 | = | 4700.0 | nM | 5.33 |