Assay Detail
Functional
CHEMBL3240643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human OX1 receptor assessed as Ca2+ flux by FLIPR assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.89 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3235265 | — | — | 1 | 8.20 |
| CHEMBL3235249 | — | — | 1 | 7.80 |
| CHEMBL3235253 | — | — | 1 | 7.51 |
| CHEMBL3235260 | — | — | 1 | 7.23 |
| CHEMBL3235255 | — | — | 1 | 7.08 |
| CHEMBL3235254 | — | — | 1 | 7.00 |
| CHEMBL3235251 | — | — | 1 | 6.85 |
| CHEMBL3235264 | — | — | 1 | 6.53 |
| CHEMBL3235252 | — | — | 1 | 6.15 |
| CHEMBL3235250 | — | — | 1 | 6.07 |
| CHEMBL3235258 | — | — | 1 | 5.41 |
| CHEMBL3235259 | — | — | 1 | - |
| CHEMBL3235261 | — | — | 1 | - |
| CHEMBL3235262 | — | — | 1 | - |
| CHEMBL3235263 | — | — | 1 | - |
| CHEMBL3235257 | — | — | 1 | - |
| CHEMBL3235256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3235265 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3235249 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3235253 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3235260 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3235255 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3235254 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3235251 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3235264 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL3235252 | — | IC50 | = | 706.0 | nM | 6.15 |
| CHEMBL3235250 | — | IC50 | = | 861.0 | nM | 6.07 |
| CHEMBL3235258 | — | IC50 | = | 3878.0 | nM | 5.41 |
| CHEMBL3235259 | — | IC50 | - | — | - | |
| CHEMBL3235261 | — | IC50 | - | — | - | |
| CHEMBL3235262 | — | IC50 | - | — | - | |
| CHEMBL3235263 | — | IC50 | - | — | - | |
| CHEMBL3235257 | — | IC50 | - | — | - | |
| CHEMBL3235256 | — | IC50 | - | — | - |