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Assay Detail

CHEMBL3240935

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse J774A1 cells assessed as cell viability after 24 hrs by Trypan blue exclusion assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type J774.A1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

1,2,3,4,8,9,10,11-octahydrobenzo[j]phenanthridine-7,12-diones as new leads against Mycobacterium tuberculosis.
Cappoen D, Claes P, Jacobs J, Anthonissen R, Mathys V, Verschaeve L, Huygen K, De Kimpe N.
J Med Chem (2014) 57 : 2895 -2907
PubMed 24611928 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.87 5.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3238348 1 5.88
CHEMBL1935195 1 5.49
CHEMBL3233066 1 5.13
CHEMBL3238360 1 5.13
CHEMBL3238350 1 5.09
CHEMBL3238358 1 5.07
CHEMBL3238352 1 4.96
CHEMBL3238349 1 4.94
CHEMBL3238351 1 4.83
CHEMBL3238356 1 4.64
CHEMBL3238353 1 4.59
CHEMBL3238354 1 4.51
CHEMBL3238359 1 4.30
CHEMBL3238355 1 4.29
CHEMBL3238357 1 4.27
CHEMBL64 ISONIAZID 4.0 1 -
CHEMBL374478 RIFAMPIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3238348 IC50 = 1310.0 nM 5.88
CHEMBL1935195 IC50 = 3210.0 nM 5.49
CHEMBL3233066 IC50 = 7340.0 nM 5.13
CHEMBL3238360 IC50 = 7330.0 nM 5.13
CHEMBL3238350 IC50 = 8130.0 nM 5.09
CHEMBL3238358 IC50 = 8490.0 nM 5.07
CHEMBL3238352 IC50 = 10900.0 nM 4.96
CHEMBL3238349 IC50 = 11490.0 nM 4.94
CHEMBL3238351 IC50 = 14910.0 nM 4.83
CHEMBL3238356 IC50 = 22950.0 nM 4.64
CHEMBL3238353 IC50 = 25680.0 nM 4.59
CHEMBL3238354 IC50 = 30790.0 nM 4.51
CHEMBL3238359 IC50 = 49760.0 nM 4.30
CHEMBL3238355 IC50 = 51350.0 nM 4.29
CHEMBL3238357 IC50 = 53230.0 nM 4.27
CHEMBL64 ISONIAZID IC50 > 100000.0 nM -
CHEMBL374478 RIFAMPIN IC50 > 100000.0 nM -