Assay Detail
Functional
CHEMBL3240948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human HeLa cells expressing CD4-LTR-beta-gal assessed as inhibition of viral replication after 3 days by reporter gene assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.46 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 7.85 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.63 |
| CHEMBL456365 | — | — | 1 | 6.08 |
| CHEMBL3238122 | — | — | 1 | 5.44 |
| CHEMBL3238126 | — | — | 1 | 4.88 |
| CHEMBL496454 | — | — | 1 | 4.85 |
| CHEMBL3238124 | — | — | 1 | 4.79 |
| CHEMBL3238130 | — | — | 1 | 4.77 |
| CHEMBL3238120 | — | — | 1 | 4.68 |
| CHEMBL3238132 | — | — | 1 | 4.58 |
| CHEMBL3238121 | — | — | 1 | 4.48 |
| CHEMBL3238131 | — | — | 1 | - |
| CHEMBL3238129 | — | — | 1 | - |
| CHEMBL3238133 | — | — | 1 | - |
| CHEMBL3238134 | — | — | 1 | - |
| CHEMBL3238128 | — | — | 1 | - |
| CHEMBL3238127 | — | — | 1 | - |
| CHEMBL3238125 | — | — | 1 | - |
| CHEMBL3238123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | EC50 | = | 14.2 | nM | 7.85 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 23.6 | nM | 7.63 |
| CHEMBL456365 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3238122 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3238126 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL496454 | — | EC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3238124 | — | EC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL3238130 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3238120 | — | EC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL3238132 | — | EC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL3238121 | — | EC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL3238131 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3238129 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3238133 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3238134 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3238128 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3238127 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3238125 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3238123 | — | EC50 | > | 50000.0 | nM | - |