Assay Detail
Binding
CHEMBL3241126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine prolyl oligopeptidase using Z-Gly-Pro-AMC as substrate after 60 mins by double-reciprocal plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.68 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189620 | — | — | 1 | 10.00 |
| CHEMBL3236273 | — | — | 1 | 8.38 |
| CHEMBL3236272 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189620 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3236273 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL3236272 | — | Ki | = | 22.0 | nM | 7.66 |