Assay Detail
Binding
CHEMBL3241349
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Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after 15 mins by Ellman's method
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 19 | - | - |
| IC50 | 8 | 5.32 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3236082 | — | — | 1 | 5.90 |
| CHEMBL3236097 | — | — | 1 | 5.88 |
| CHEMBL3235783 | — | — | 1 | 5.42 |
| CHEMBL1094079 | — | — | 1 | 5.41 |
| CHEMBL3236092 | — | — | 1 | 5.29 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.20 |
| CHEMBL3236093 | — | — | 1 | 5.12 |
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 4.31 |
| CHEMBL3235782 | — | — | 1 | - |
| CHEMBL3235784 | — | — | 1 | - |
| CHEMBL3235785 | — | — | 1 | - |
| CHEMBL3235786 | — | — | 1 | - |
| CHEMBL3236083 | — | — | 1 | - |
| CHEMBL3236084 | — | — | 1 | - |
| CHEMBL3236085 | — | — | 1 | - |
| CHEMBL3236086 | — | — | 1 | - |
| CHEMBL3236087 | — | — | 1 | - |
| CHEMBL3236088 | — | — | 1 | - |
| CHEMBL3236090 | — | — | 1 | - |
| CHEMBL3236091 | — | — | 1 | - |
| CHEMBL1094988 | — | — | 1 | - |
| CHEMBL3236094 | — | — | 1 | - |
| CHEMBL3236095 | — | — | 1 | - |
| CHEMBL3236096 | — | — | 1 | - |
| CHEMBL3236098 | — | — | 1 | - |
| CHEMBL3236099 | — | — | 1 | - |
| CHEMBL3236089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3236082 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL3236097 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3235783 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL1094079 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL3236092 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 6370.0 | nM | 5.20 |
| CHEMBL3236093 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 49100.0 | nM | 4.31 |
| CHEMBL3235782 | — | Inhibition | = | 31.1 | % | - |
| CHEMBL3235784 | — | Inhibition | = | 32.8 | % | - |
| CHEMBL3235785 | — | Inhibition | = | 31.1 | % | - |
| CHEMBL3235786 | — | Inhibition | = | 32.6 | % | - |
| CHEMBL3236083 | — | Inhibition | = | 27.2 | % | - |
| CHEMBL3236084 | — | Inhibition | = | 32.1 | % | - |
| CHEMBL3236085 | — | Inhibition | = | 37.4 | % | - |
| CHEMBL3236086 | — | Inhibition | = | 1.18 | % | - |
| CHEMBL3236087 | — | Inhibition | = | 35.4 | % | - |
| CHEMBL3236088 | — | Inhibition | = | 24.8 | % | - |
| CHEMBL3236090 | — | Inhibition | = | 26.2 | % | - |
| CHEMBL3236091 | — | Inhibition | = | 25.7 | % | - |
| CHEMBL1094988 | — | Inhibition | = | 41.8 | % | - |
| CHEMBL3236094 | — | Inhibition | = | 36.2 | % | - |
| CHEMBL3236095 | — | Inhibition | = | 41.2 | % | - |
| CHEMBL3236096 | — | Inhibition | = | 18.21 | % | - |
| CHEMBL3236098 | — | Inhibition | = | 33.5 | % | - |
| CHEMBL3236099 | — | Inhibition | = | 28.1 | % | - |
| CHEMBL3236089 | — | Inhibition | = | 34.6 | % | - |