Assay Detail
Binding
CHEMBL3241376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT2 using Fluor-de-Lys as substrate incubated for 60 mins prior to substrate addition measured after 60 mins by fluorometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel SIRT2-selective inhibitors using a click chemistry approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.31 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224864 | — | — | 1 | 5.46 |
| CHEMBL3236132 | — | — | 1 | 5.28 |
| CHEMBL3236133 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224864 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3236132 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3236133 | — | IC50 | = | 6300.0 | nM | 5.20 |