Assay Detail
Binding
CHEMBL3241469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in SK-N-MC cells after 45 mins by competition binding analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.59 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3236553 | — | — | 1 | 7.62 |
| CHEMBL3236568 | — | — | 1 | 6.17 |
| CHEMBL3236549 | JNJ-39758979 | 2.0 | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3236553 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3236568 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL3236549 | JNJ-39758979 | Ki | = | 1043.0 | nM | 5.98 |