Assay Detail
Binding
CHEMBL3241715
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Antagonist activity at mineralocorticoid receptor (unknown origin) by PathHunter assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.41 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1393 | SPIRONOLACTONE | 4.0 | 1 | 7.96 |
| CHEMBL3234858 | — | — | 1 | 7.41 |
| CHEMBL3234850 | — | — | 1 | 7.17 |
| CHEMBL3234863 | — | — | 1 | 7.09 |
| CHEMBL3234861 | — | — | 1 | 6.89 |
| CHEMBL3234856 | — | — | 1 | 6.80 |
| CHEMBL3234847 | — | — | 1 | 6.62 |
| CHEMBL3234848 | — | — | 1 | 6.62 |
| CHEMBL1095097 | EPLERENONE | 4.0 | 1 | 6.61 |
| CHEMBL3234849 | — | — | 1 | 6.57 |
| CHEMBL3234859 | — | — | 1 | 6.57 |
| CHEMBL3234855 | — | — | 1 | 6.42 |
| CHEMBL3234862 | — | — | 1 | 6.33 |
| CHEMBL3234852 | — | — | 1 | 6.18 |
| CHEMBL3234854 | — | — | 1 | 6.17 |
| CHEMBL3234846 | — | — | 1 | 5.96 |
| CHEMBL3234853 | — | — | 1 | 5.88 |
| CHEMBL3234851 | — | — | 1 | 5.84 |
| CHEMBL3234860 | — | — | 1 | 5.82 |
| CHEMBL3234845 | — | — | 1 | 5.77 |
| CHEMBL2407661 | — | — | 1 | 5.22 |
| CHEMBL3234857 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1393 | SPIRONOLACTONE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3234858 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3234850 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3234863 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3234861 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3234856 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3234847 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3234848 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1095097 | EPLERENONE | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL3234849 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3234859 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3234855 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3234862 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3234852 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3234854 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3234846 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL3234853 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3234851 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3234860 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL3234845 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2407661 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3234857 | — | IC50 | = | 6740.0 | nM | 5.17 |