Assay Detail
Binding
CHEMBL3241789
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Inhibition of Plasmodium falciparum plasmepsin 2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.46 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3236067 | — | — | 1 | 9.00 |
| CHEMBL3236066 | — | — | 1 | 8.96 |
| CHEMBL3236064 | — | — | 1 | 8.92 |
| CHEMBL3236063 | — | — | 1 | 8.77 |
| CHEMBL3236065 | — | — | 1 | 8.64 |
| CHEMBL3236069 | — | — | 1 | 8.37 |
| CHEMBL3236061 | — | — | 1 | 8.36 |
| CHEMBL3236062 | — | — | 1 | 8.32 |
| CHEMBL3236058 | — | — | 1 | 8.26 |
| CHEMBL3236068 | — | — | 1 | 8.24 |
| CHEMBL3236059 | — | — | 1 | 7.96 |
| CHEMBL3236060 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3236067 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3236066 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3236064 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3236063 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3236065 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3236069 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL3236061 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL3236062 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL3236058 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL3236068 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL3236059 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3236060 | — | Ki | = | 22.0 | nM | 7.66 |