Assay Detail
Functional
CHEMBL3241875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse multidrug-resistant TA3-MTX-R cells after 48 hrs by neutral red assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | TA3-MTX-R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on cancer cell lines. Validation in vivo in singenic mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.44 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3234100 | — | — | 1 | 6.42 |
| CHEMBL3234102 | — | — | 1 | 5.92 |
| CHEMBL16121 | DODECYL GALLATE | — | 1 | 5.52 |
| CHEMBL3234101 | — | — | 1 | 5.43 |
| CHEMBL3234099 | — | — | 1 | 4.84 |
| CHEMBL277346 | OCTYL_GALLATE | — | 1 | 4.53 |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | - |
| CHEMBL1448331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3234100 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3234102 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL16121 | DODECYL GALLATE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3234101 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3234099 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL277346 | OCTYL_GALLATE | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL288114 | GALLIC ACID | IC50 | = | 160200.0 | nM | - |
| CHEMBL1448331 | — | IC50 | > | 200000.0 | nM | - |