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Assay Detail

CHEMBL3241876

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Functional
Cytotoxicity against human CCRF-CEM cells after 48 hrs by neutral red assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on cancer cell lines. Validation in vivo in singenic mice.
Jara JA, Castro-Castillo V, Saavedra-Olavarría J, Peredo L, Pavanni M, Jaña F, Letelier ME, Parra E, Becker MI, Morello A, Kemmerling U, Maya JD, Ferreira J.
J Med Chem (2014) 57 : 2440 -2454
PubMed 24568614 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 5.04 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3234102 1 6.24
CHEMBL3234100 1 5.78
CHEMBL16121 DODECYL GALLATE 1 4.81
CHEMBL3234101 1 4.70
CHEMBL3234099 1 4.46
CHEMBL277346 OCTYL_GALLATE 1 4.23
CHEMBL1448331 1 -
CHEMBL288114 GALLIC ACID 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3234102 IC50 = 580.0 nM 6.24
CHEMBL3234100 IC50 = 1650.0 nM 5.78
CHEMBL16121 DODECYL GALLATE IC50 = 15460.0 nM 4.81
CHEMBL3234101 IC50 = 19750.0 nM 4.70
CHEMBL3234099 IC50 = 34600.0 nM 4.46
CHEMBL277346 OCTYL_GALLATE IC50 = 58500.0 nM 4.23
CHEMBL1448331 IC50 = 184000.0 nM -
CHEMBL288114 GALLIC ACID IC50 > 200000.0 nM -