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Assay Detail

CHEMBL3242435

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Functional
Cytotoxicity against human CHP100 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHP100
Confidence 1 — Organism
Curated By Autocuration

Publication

Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.
Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA.
J Med Chem (2014) 57 : 2851 -2863
PubMed 24625088 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.29 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3233027 1 6.66
CHEMBL2047407 1 6.64
CHEMBL3234489 1 6.55
CHEMBL3234490 1 6.51
CHEMBL3234488 1 6.46
CHEMBL3234472 1 6.46
CHEMBL3234486 1 6.41
CHEMBL3234477 1 6.41
CHEMBL3234479 1 6.28
CHEMBL2047410 1 6.19
CHEMBL3234476 1 6.14
CHEMBL3234473 1 6.12
CHEMBL3234471 1 6.11
CHEMBL3234485 1 6.09
CHEMBL3234487 1 6.08
CHEMBL3234482 1 6.03
CHEMBL3234466 1 6.02
CHEMBL517080 WITHAFERIN A 1.0 1 6.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3233027 IC50 = 220.0 nM 6.66
CHEMBL2047407 IC50 = 230.0 nM 6.64
CHEMBL3234489 IC50 = 280.0 nM 6.55
CHEMBL3234490 IC50 = 310.0 nM 6.51
CHEMBL3234488 IC50 = 350.0 nM 6.46
CHEMBL3234472 IC50 = 350.0 nM 6.46
CHEMBL3234486 IC50 = 390.0 nM 6.41
CHEMBL3234477 IC50 = 390.0 nM 6.41
CHEMBL3234479 IC50 = 530.0 nM 6.28
CHEMBL2047410 IC50 = 640.0 nM 6.19
CHEMBL3234476 IC50 = 730.0 nM 6.14
CHEMBL3234473 IC50 = 760.0 nM 6.12
CHEMBL3234471 IC50 = 780.0 nM 6.11
CHEMBL3234485 IC50 = 810.0 nM 6.09
CHEMBL3234487 IC50 = 830.0 nM 6.08
CHEMBL3234482 IC50 = 930.0 nM 6.03
CHEMBL3234466 IC50 = 960.0 nM 6.02
CHEMBL517080 WITHAFERIN A IC50 = 970.0 nM 6.01