Assay Detail
Binding
CHEMBL3242722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIRT2 (unknown origin) by luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.46 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233749 | — | — | 1 | 4.89 |
| CHEMBL3233733 | — | — | 1 | 4.50 |
| CHEMBL491960 | CAMBINOL | — | 1 | 4.29 |
| CHEMBL3233748 | — | — | 1 | 4.17 |
| CHEMBL3233739 | — | — | 1 | - |
| CHEMBL3233742 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233749 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3233733 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL491960 | CAMBINOL | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL3233748 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL3233739 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3233742 | — | IC50 | > | 200000.0 | nM | - |