Assay Detail
Functional
CHEMBL3242888
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Antiproliferative activity against human Dakiki cells assessed as growth inhibition after 72 hrs by Cell Titer Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Dakiki |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.62 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233749 | — | — | 1 | 5.16 |
| CHEMBL3233742 | — | — | 1 | 4.54 |
| CHEMBL3233733 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233749 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3233742 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3233733 | — | IC50 | = | 68000.0 | nM | 4.17 |