Assay Detail
Binding
CHEMBL3243052
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Binding affinity to MDM2 in human SJSA1 cells assessed as upregulation of p21 mRNA expression after 7 hrs by qRT-PCR analysis in absence of human serum
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SJSA-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.18 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3125527 | — | — | 1 | 7.74 |
| CHEMBL3233130 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3125527 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL3233130 | — | IC50 | = | 240.0 | nM | 6.62 |