Assay Detail
Functional
CHEMBL3243107
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Inhibition of TNF-alpha production in rat RBL2H3 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.60 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216481 | VIALININ B | — | 1 | 10.30 |
| CHEMBL2012938 | VIALININ A | — | 1 | 9.60 |
| CHEMBL3236516 | — | — | 1 | 8.46 |
| CHEMBL3236515 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216481 | VIALININ B | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL2012938 | VIALININ A | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL3236516 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3236515 | — | IC50 | = | 890.0 | nM | 6.05 |