Compound Detail
CHEMBL216481
VIALININ B Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
O=C(Cc1ccccc1)Oc1c(-c2ccc(O)cc2)c(O)c2oc3cc(O)c(O)cc3c2c1OC(=O)Cc1ccccc1
Basic Information
| ChEMBL ID | CHEMBL216481 |
| Name | VIALININ B |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FMUSGJFTMXBKQN-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
576.6
MW (Da)
6.37
ALogP
9
HBA
4
HBD
146.7
PSA (Ų)
0.10
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 10.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RBL-2H3 CHEMBL614632 | IC50 | 10.7 | 10.5 | 0.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RBL-2H3 | IC50 | = | 0.02 | nM | 10.7 | Inhibition of DNP7-BSA antigen-induced TNFalpha release in rat RBL-2H3 cells | 16901696 |
| RBL-2H3 | IC50 | = | 0.05 | nM | 10.3 | Inhibition of TNF-alpha production in rat RBL2H3 cells | 24679673 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16901696 | 10.1016/j.bmcl.2006.07.068 | RBL-2H3 | 1 |
| 24679673 | 10.1016/j.bmc.2014.02.058 | RBL-2H3 | 1 |
Data from ChEMBL 36 via Core Engine