Assay Detail
Functional
CHEMBL907005
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Inhibition of DNP7-BSA antigen-induced TNFalpha release in rat RBL-2H3 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Vialinin B, a novel potent inhibitor of TNF-alpha production, isolated from an edible mushroom, Thelephora vialis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.77 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216481 | VIALININ B | — | 1 | 10.70 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.60 |
| CHEMBL219810 | CYCLOLEUCOMELONE | — | 1 | 5.46 |
| CHEMBL384074 | GANBAJUNIN B | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216481 | VIALININ B | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL219810 | CYCLOLEUCOMELONE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL384074 | GANBAJUNIN B | IC50 | = | 5000.0 | nM | 5.30 |