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Assay Detail

CHEMBL3243451

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Functional
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as protection from cytopathic effect
ChEMBL ↗
107
Total Activities
107
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

QSAR models for HEPT derivates as NNRTI inhibitors based on Monte Carlo method.
Toropova AP, Toropov AA, Veselinović JB, Miljković FN, Veselinović AM.
Eur J Med Chem (2014) 77 : 298 -305
PubMed 24657566 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 107 5.25 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL330759 — — 1 5.46
CHEMBL119904 — — 1 5.46
CHEMBL116471 — — 1 5.45
CHEMBL117945 — — 1 5.45
CHEMBL16686 — — 1 5.44
CHEMBL118078 — — 1 5.44
CHEMBL114560 — — 1 5.44
CHEMBL116556 — — 1 5.44
CHEMBL117196 — — 1 5.44
CHEMBL3234190 — — 1 5.44
CHEMBL290413 — — 1 5.44
CHEMBL116799 — — 1 5.43
CHEMBL274458 — — 1 5.42
CHEMBL290685 — — 1 5.42
CHEMBL116566 — — 1 5.41
CHEMBL116695 — — 1 5.40
CHEMBL419485 — — 1 5.40
CHEMBL279637 — — 1 5.39
CHEMBL280279 — — 1 5.38
CHEMBL440274 — — 1 5.36
CHEMBL445061 — — 1 5.36
CHEMBL16824 — — 1 5.35
CHEMBL142593 — — 1 5.35
CHEMBL310743 — — 1 5.34
CHEMBL278944 — — 1 5.33
CHEMBL17097 — — 1 5.33
CHEMBL117005 — — 1 5.33
CHEMBL445122 — — 1 5.33
CHEMBL311494 — — 1 5.33
CHEMBL36719 — — 1 5.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL119904 — IC50 = 3450.0 nM 5.46
CHEMBL330759 — IC50 = 3510.0 nM 5.46
CHEMBL117945 — IC50 = 3560.0 nM 5.45
CHEMBL116471 — IC50 = 3530.0 nM 5.45
CHEMBL290413 — IC50 = 3600.0 nM 5.44
CHEMBL3234190 — IC50 = 3600.0 nM 5.44
CHEMBL117196 — IC50 = 3600.0 nM 5.44
CHEMBL116556 — IC50 = 3600.0 nM 5.44
CHEMBL114560 — IC50 = 3600.0 nM 5.44
CHEMBL118078 — IC50 = 3600.0 nM 5.44
CHEMBL16686 — IC50 = 3660.0 nM 5.44
CHEMBL116799 — IC50 = 3720.0 nM 5.43
CHEMBL290685 — IC50 = 3820.0 nM 5.42
CHEMBL274458 — IC50 = 3850.0 nM 5.42
CHEMBL116566 — IC50 = 3890.0 nM 5.41
CHEMBL116695 — IC50 = 3960.0 nM 5.40
CHEMBL419485 — IC50 = 4000.0 nM 5.40
CHEMBL279637 — IC50 = 4090.0 nM 5.39
CHEMBL280279 — IC50 = 4150.0 nM 5.38
CHEMBL445061 — IC50 = 4370.0 nM 5.36
CHEMBL440274 — IC50 = 4350.0 nM 5.36
CHEMBL142593 — IC50 = 4460.0 nM 5.35
CHEMBL16824 — IC50 = 4470.0 nM 5.35
CHEMBL310743 — IC50 = 4520.0 nM 5.34
CHEMBL445122 — IC50 = 4720.0 nM 5.33
CHEMBL36719 — IC50 = 4700.0 nM 5.33
CHEMBL117005 — IC50 = 4680.0 nM 5.33
CHEMBL278944 — IC50 = 4720.0 nM 5.33
CHEMBL311494 — IC50 = 4700.0 nM 5.33
CHEMBL17097 — IC50 = 4660.0 nM 5.33
CHEMBL120131 — IC50 = 4740.0 nM 5.32
CHEMBL117653 — IC50 = 4740.0 nM 5.32
CHEMBL419228 — IC50 = 4890.0 nM 5.31
CHEMBL333997 — IC50 = 4920.0 nM 5.31
CHEMBL418726 — IC50 = 4890.0 nM 5.31
CHEMBL276058 — IC50 = 4920.0 nM 5.31
CHEMBL279579 — IC50 = 5000.0 nM 5.30
CHEMBL37833 — IC50 = 5060.0 nM 5.30
CHEMBL16628 — IC50 = 5000.0 nM 5.30
CHEMBL417448 — IC50 = 5000.0 nM 5.30
CHEMBL3233960 — IC50 = 5120.0 nM 5.29
CHEMBL16763 — IC50 = 5100.0 nM 5.29
CHEMBL117433 — IC50 = 5140.0 nM 5.29
CHEMBL325458 — IC50 = 5180.0 nM 5.29
CHEMBL3233959 — IC50 = 5170.0 nM 5.29
CHEMBL31871 HEPT IC50 = 5150.0 nM 5.29
CHEMBL280068 — IC50 = 5240.0 nM 5.28
CHEMBL120535 — IC50 = 5220.0 nM 5.28
CHEMBL38039 — IC50 = 5240.0 nM 5.28
CHEMBL343948 — IC50 = 5400.0 nM 5.27