Assay Detail
Functional
CHEMBL3243493
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Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.90 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3234202 | — | — | 1 | 9.16 |
| CHEMBL3234200 | — | — | 1 | 8.90 |
| CHEMBL2022564 | APRATOXIN S4 | — | 1 | 8.85 |
| CHEMBL3234201 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3234202 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL3234200 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL2022564 | APRATOXIN S4 | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL3234201 | — | IC50 | = | 1.99 | nM | 8.70 |