Assay Detail
Binding
CHEMBL3243862
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Inhibition of adrenergic alpha1B receptor (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.05 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233142 | LUMATEPERONE TOSYLATE | 4.0 | 1 | 7.51 |
| CHEMBL3233412 | — | — | 1 | 7.18 |
| CHEMBL3233432 | — | — | 1 | 6.98 |
| CHEMBL3233411 | — | — | 1 | 6.53 |
| CHEMBL3233143 | — | — | 1 | - |
| CHEMBL3233427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233142 | LUMATEPERONE TOSYLATE | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3233412 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL3233432 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL3233411 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL3233143 | — | Ki | - | — | - | |
| CHEMBL3233427 | — | Ki | - | — | - |